Profit Forecast Calculator



Profit Forecast Calculator uses data on revenue and costs to output Gross Profit Margin, Profit Margin, and Net Income. This forecast model is a useful tool for preliminary assessment whether a product is worth developing.
General Description
Notably, when an NPV range is calculated for one input range, all other inputs are held constant at their Base values.
Select Geography
Launch Year
2025
2044






















Revenue & Costs
-$78M
-$39M
$0
$39M
$78M
$118M
Revenue
COGS
M&R
R&D
Commercial
G&A
Tax
2025
2027
2029
2031
2033
2035
2037
2039
2041
2043
Profit Margins
0%
20%
40%
60%
80%
100%
Gross Profit Margin
Profit Margin
Matching Profit Margin
2025
2027
2029
2031
2033
2035
2037
2039
2041
2043
Net Income
-$113M
-$76M
-$38M
$0
$38M
$76M
2025
2027
2029
2031
2033
2035
2037
2039
2041
2043
Download: Charts Image · Inputs CSV · Data CSV

Revenue Inputs
The underlying revenue algorithm is the same as the one in the Revenue Forecast Calculator. If you are not sure how to select revenue parameters, we recommend testing the revenue calculator first.
Costs
In this calculator, users can get insights into how cost parameters influence Gross Profit Margin, Profit Margin, and Net Income. Profit

Finally, the calculator outputs Gross Profit and Profit margins, as well as Net Income. Formulas for calculating these parameters are as follows. Usually, Milestones/Royalties are more complicated. Milestones include a variety of payments paid out overtime. Royalties are an example of variable cost and is part of COGS. Here, we express Royalties as % of sales without consideration of tiers. Specifically, Operating Expenses include R&D, Commercial, and G&A expenses. Importantly, Profit represents EBITDA (Earnings Before Interest, Taxes, Depreciation, Appreciation). Similarly, here Net Income represents NOPAT (Net Operating Income After Tax).

Certainly, Profit assessment is important. However, Net Present Value (NPV) helps more accurately answer the question “is it worth developing a product?”. To estimate NPV, please visit our non-risk adjusted and risk-adjusted calculators.

Confused? Stuck? Please send any questions, comments, and requests to bioheights@pm.me.

Please Subscribe below to receive email notifications about new tools and blog posts. Also, check out our blog articles on the Insights page.

Disclaimer: This Profit Forecast Calculator is the property of BioHeights LLC. We designed this model only for educational purposes. Importantly, this is not a financial advice. BioHeights LLC and its members are not responsible for anybody’s actions, losses, or damages resulting from using this model.

Sign Up to Receive the Latest Insights
Enter your email address to receive notifications about new articles, tools, and updates.
Sign Up Here

Solve a Problem: CGTx Product Profit

Consider a hypothetical scenario of an investigational drug for SMA1 that treats all new cases with a single, one-time infusion. Consider only U.S. market. U.S. Launch in 2026. Ramp 3 Years. No competition.
Price per dose $500k. Cost per dose $250k. R&D expenses $700M. Launch Expenses $300M. Royalties 9%.

1. If production of the drug can be optimized to reduce cost per dose 5X (to $50k), how would profit margin change in 2029?
  X   Decrease 5 times
  X   Increase 5 times
  X   No change
  X   Decrease 2 times
  V   Increase 2 times

2. Assume that this product includes a proprietary viral component (AAV9) that belongs to another party. By Launch, the company have to pay the licensor $100M in Development milestones and additional $100M in Launch milestones. Should it negotiate down Royalties or Milestones?
  V   Check th sensitivity of the model to each parameter. It also depends on parameters that are not in this calculator. Check risk-adjusted NPV calculator for more accurate assessment.


Solve a Problem: Small Peptide Product Profit

Drug for Type 2 Diabetes. Patient segment 3%. Launch 2026. Ramp 7 Years. Market share 40%. Price per week $60. Cost per weekly dose $6. R&D expenses $900M. Launch Expenses $400M. Sales & marketing 10%

1. If production of the drug can be optimized to reduce cost 6X (to $1 per weekly dose), how would Profit Margin change in 2029?
  X   Increase 6X
  X   Increase 2X
  V   Less than 10% change
  X   Decrease 2X

2. Which scenario is more profitable? #1: Increase commercial expenses in perpetuity from 10% to 12%, to increase market share from 40% to 50%. #2: Decrease cost of weekly dose from $6 to $1. Hint: How would Net Income change in 2029?
  V   Scenario 1
  X   Scenario 2